the SIRT3 gene sequence

QUESTION

Researchers analyzing the SIRT3 gene sequence engineer a SIRT3 gene that is identical to the normal gene except that a single nucleotide has been deleted from the 5′ end of the second exon of th

Researchers analyzing the  SIRT3  gene sequence engineer a  SIRT3  gene that is identical to the normal gene except that a single nucleotide has been deleted from the  5′  end of the second exon of the gene; the deletion does not affect splicing. The researchers introduce this gene into normal stomach cells to determine how the primary AND tertiary structures of the protein expressed from the engineered  SIRT3  gene will compare with the protein expressed from the normal  SIRT3  gene in these cells. Predict the results of this experiment. The researchers claim that the data in Figure 3 provide evidence that the stomach cancer cells perform fermentation to a greater extent than do normal stomach cells. Provide reasoning to justify the claim. Based on the information provided, predict the effect on the ratio of  NADH/NAD+  in the cells treated with the compound that blocks the electron transport chain compared with similar cells not treated with the compound.

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