major cell cycle7cell death regulators

QUESTION

Please, answer the questions for the following major cell cycle7cell death regulators, which are also involved in many cancer types. 1) RAS 2) MYC 3) p53 4) pRB Questions : a) protein’s funct

Please, answer the questions for the following major cell cycle7cell death regulators, which are also involved in many cancer types.

1) RAS

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2) MYC

3) p53

4) pRB

Questions :

a) protein’s function (is it a transcription factor);

b) regulators (does it have bound partners?, is it monomeric);

c) how is the protein affecting cell cycle progression in normal cells? in cancer cells? (flow diagrams are welcome);

d) is this protein target for cancer therapy development;

e) In which kind of cancer cells it is mutant? What kind of mutations are common?