signal transduction strategies

QUESTION

Consider the role that these few domains (tyrosine-kinase) play in signal transduction strategies. Please express your thoughts on how combinations of these domains contribute to both general function

Consider the role that these few domains (tyrosine-kinase) play in signal transduction strategies. Please express your thoughts on how combinations of these domains contribute to both general functions and to specificity in the signal transduction pathways.

2_Briefly explain, under what general circumstances you think that each of the three signaling concepts listed below is important. (Think of the general types of external signal to the types of internal responses. For example, signal amplification would be very important when a very low concentration of external signal is bound by a single receptor on a cell and the cell is expected to respond.  A single cytoplasmic response messenger would probably not be enough to trigger a transcriptional response.  Also, there may be multiple transcriptional elements that need to be activated and a cytoplasmic response would therefore need to be further amplified. Pick another situation where signals would need to be amplified in order to answer a.)

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a_Signal amplification

b_Signal redundancy (more than one way to activate a gene)

c_Signal reinforcement (the need for co-activation by two or more signals)