individual APECED patient

QUESTION

Each individual APECED patient has a different set of symptoms and a different set of autoantibodies. What general principle of immunology does this fact illustrate? Group of answer choices A.CD4+ T

Each individual APECED patient has a different set of symptoms and a different set of autoantibodies.  What general principle of immunology does this fact illustrate?

Group of answer choices

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A.CD4+ T cells are central to the immune response against essentially all types of pathogens.

B.TCR and BCR specificities are generated randomly.

C. The innate and adaptive arms of the immune system work together to combat infections.

D.The immune system is tolerant to self-antigens but responds vigorously to foreign antigens.